Francesca Lecce

Medico ginecologo


Nome e cognome:  Francesca Lecce
Specialità e qualifica: Medico Ginecologo
Sede di lavoro: Centro Ricerche Cliniche 


Graduation with Laude in Gynecology and Obstetrics at the Department of Gynecological, Obstetrics and Urologic Sciences of “Sapienza” University (Rome) - Policlinico Umberto I Hospital (Director: Prof. Pierluigi Benedetti Panici)

Collaboration as medical assistance in the unit of gynaecology and obstetrics of “Clinica Città di Aprilia” (Dott. G. Testa)

Research Doctorate (PhD) in Oncology (Gynaecologic and Obstetrics Sciences), 1 year program, at Department of Medical Surgical Sciences and Translational Medicine of “Sapienza” University (Rome)


Education and Training

July 2003: High school diploma with qualification in scientific studies.

October 2011: Medical degree at University “Sapienza” of Rome (110/110).

February 2012: State examination (268.75/270) and medical license to practise.

March 2012: Enrolled in “Ordine dei Medici Chirurghi e degli Odontoiatri di Latina”, number 3715.

January – December 2009: Medical assistant at Department of Radiology, Oncology and Pathological Anatomy of University “Sapienza” of Rome (Prof. Andrea Laghi).

January 2010 – October 2011: Medical assistant at Department of Internal Medicine and Medical Specialties; and at Department of Sciences and Medico-Surgical Biotechnologies of University “Sapienza” of Rome (Prof. Domenico Alvaro, Dott. Vincenzo Cardinale).


Training Aboard

March 2014 – March 2015: Clinical and Research Fellow in Oncology Gynecology in the Unit of Oncology Gynecology of “Fondazione IRCCS Istituto Nazionale Tumori di Milano” (Prof. Francesco Raspagliesi, Dott.ssa Domenica Lo Russo).

March 2015: Visiting Fellow with the accreditation of the“Intensive course in gynecologic oncology scanning and implementation of ultrasound into the management of patients with gynecological cancer” in the Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University, Prague (Prof. Daniela Fischerova, Prof. David Cibula, Prof. Michal Zikàn).

April 2015: Accreditation to International Ovarian Tumor Analysis (IOTA) during the 2th International IOTA Congress in Leuven. IOTA Steering Committee ( Prof. Dirk Timmerman, Prof. Tom Bourne, Prof. AC Testa, Prof. Lil Valentin, Prof. Ben Van Calster, Prof. Sabine Van Huffel, Prof. Ignace Vergote) 

June – December 2015: Clinical and Research Fellow in Gynaecologic Oncologic Ultrasounds in the Department of Obstetrics and Gynecology, Catholic University of Sacred Heart of Rome (Prof. Giovanni Scambia, Prof.ssa Antonia Carla Testa).



1. Di Donato V, Musella A, Casorelli A, Lecce F, Bracchi C, Marchetti C, Palaia I, Monti M, Carraro C, Muzii L, Banedetti Panici P. Uterine asymptomatic myomas: an overview from diagnosis to treatment. The Journal of Minimally Invasive Gynecology. In Press

2.Domenici L., Musella A., Bracchi C., Lecce F., Schiavi M.C., Colagiovanni V., Di Donato V., Marchetti C,. Tomao F., Palaia I., Muzii L., Benedetti Panici P. Comparison of anogenital distance and correlation with vulvo-vaginal atrophy: a pilot study on premenopausal and postmenopausal women. Journal of Menopausal Medicine 2018,24 1-5

3. Marchetti C, De Felice F, Perniola G, Lecce F, Vertechy L, Monti M, Musio D, Muzii L, Tombolini V, Benedetti Panici P. Screening program in ovarian cancer: A logical step in clinical management? A meta-analysis. Curr Probl Cancer. 2018 Mar- Apr;42(2):235-240

4. Di Donato V, Bracchi C, Cigna E, Domenici L, Musella A, Giannini A, Lecce F, Marchetti C, Benedetti Panici P. Vulvo-vaginal reconstruction after radical excision for treatment of vulvar cancer: Evaluation of feasibility and morbidity of different surgical techniques. Surg Oncol. 2017 Dec;26(4):511-521.

5. Muzii L, Domenici L, Lecce F, Di Feliciantonio M, Frantellizzi R, Marchetti C, Monti M, Benedetti Panici P. Clinical outcome after resectoscopic treatment of cesarean-induced isthmocele: a prospective case-control study. European Review for Medical and Pharmacological Sciences. 2017;21:3341-3346

6. Domenici L., Di Donato V., Colagiovanni V., Piccioni M.G., Musella A., Marchetti C., Tomao F., Perniola G., Palaia I., Maturo A., Schiavi M.C., Lecce F., Bracchi C., Casorelli A., Muzii L., Monti M., Benedetti Panici P. Update on fertility-sparing treatment in primary and recurrent endometrial cancer. Giorn It Ost Gin 29(1):16-20 · January 2017

7. Di Donato V, Kontopantelis E, Aletti G, Casorelli A, Piacenti I, Bogani G,Lecce F, Benedetti Panici P. Trends in Mortality After Primary Cytoreductive Surgery for Ovarian Cancer: A Systematic Review and Metaregression of Randomized Clinical Trials and Observational Studies. Ann Surg Oncol. 2017 Jun;24(6):1688-1697. Epub 2016 Nov 28. Review.

8. Domenici L, Perniola G, Giorgini M, Lecce F, Bracchi C, Musella A, Marchetti C, Di Donato V,Tomao F, Palaia I, Ciolli P, Recine N, Muzii L, Benedetti Panici P. Vulvodynia: current opinion and treatment strategies. Minerva Ginecol. 2016 Dec;68(6):727-32. Epub 2015 Jun 30.

9. Bogani G, Sabatucci I, Maltese G, Lecce F, Signorelli M, Martinelli F, Chiappa V, Indini A, Leone Roberti Maggiore U, Borghi C, Fucà G, Ditto A, Raspagliesi F, Lorusso D. Chemotherapy-related leukopenia as a biomarker predicting survival outcomes in locally advanced cervical cancer. Eur J Obstet Gynecol Reprod Biol. 2017 Jan;208:41-45. Epub 2016 Nov 19.

10. Bogani G, Fucà G, Maltese G, Ditto A, Martinelli F, Signorelli M, Chiappa V, Scaffa C, Sabatucci I, Lecce F, Raspagliesi F, Lorusso D. Efficacy of adjuvant chemotherapy in early stage uterine leiomyosarcoma: A systematic review and meta-analysis. Gynecol Oncol. 2016 Nov;143(2):443-447. Epub 2016 Jul 29. Review.

11. Muzii L, Achilli C, Bergamini V, Candiani M, Garavaglia E, Lazzeri L, Lecce F, Maiorana A, Maneschi F, Marana R, Perandini A, Porpora MG, Seracchioli R, Spagnolo E, Vignali M, Benedetti Panici P. Comparison between the stripping technique and the combined excisional/ablative technique for the treatment of bilateral ovarian endometriomas: a multicentre RCT. Hum Reprod. 2016 Feb;31(2):339-44. Epub 2015 Dec 18.

12. Alessi A, Martinelli F, Padovano B, Serafini G, Lorusso D, Lorenzoni A, Ditto A, Lecce F, Mira M, Donfrancesco C, Raspagliesi F, Crippa F. FDG-PET/CT to predict optimal primary cytoreductive surgery in patients with advanced ovarian cancer: preliminary results. Tumori. 2016 Jan-Feb;102(1):103-7. Epub 2015 Aug 4.

13. Musella A, Marchetti C, Palaia I, Perniola G, Giorgini M, Lecce F, Vertechy L, Iadarola R, De Felice F, Monti M, Muzii L, Angioli R, Panici PB. Secondary Cytoreduction in Platinum-Resistant Recurrent Ovarian Cancer: A Single-Institution Experience. Ann Surg Oncol. 2015 Dec;22(13):4211-6.

14. Panici PB, Di Donato V, Palaia I, Visentin VS, Marchetti C, Perniola G, Musella A, Gasparri ML,
Lecce F, Sabatucci I, Monti M, Muzii L. Type B versus Type C Radical Hysterectomy After
Neoadjuvant Chemotherapy in Locally Advanced Cervical Carcinoma: A Propensity-Matched
Analysis. Ann Surg Oncol. 2016 Jul;23(7):2176-82. Epub 2015 Nov 23.

15. Martinelli F, Bogani G, Ditto A, Carcangiu M, Papadia A, Lecce F, Chiappa V, Lorusso D, Raspagliesi F. How often parametrial involvement leads to post-operative adjuvant treatment in locally advanced cervical cancer after neoadjuvant chemotherapy and type C radical hysterectomy? Eur J Surg Oncol. 2015 Aug;41(8):1089-96. Epub 2015 Apr 7.

16. Gasparri ML, Bellati F, Brunelli R, Perrone G, Pecorini F, Papadia A, Meloni G, Trisolini SM,
Gozzer M, Domenici L, Lecce F, Benedetti Panici P. Thrombotic thrombocytopenic purpura during
pregnancy versus imitator of preeclampsia. Transfusion. 2015 Oct;55(10):2516-8. Epub 2015 Aug 10.

17. Muzii L, Achilli C, Lecce F, Bianchi A, Franceschetti S, Marchetti C, Perniola G, Panici PB. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril. 2015 Mar;103(3):738-43. Epub 2015 Jan 7.

18. Domenici L, Di Donato V, Gasparri ML, Lecce F, Caccetta J, Panici PB. Laparotomic myomectomy in the 16th week of pregnancy: a case report. Case Rep Obstet Gynecol. 2014;2014:154347. Epub 2014 Mar 4.

19. Muzii L, Lecce F, Achilli C, Antonilli M, Musella A, Palaia I, Benedetti Panici P. Endometrioma-associated infertility: is surgery still the best way to go?
J Endometr Pelvic Pain Disord 2013; 5(4): 127 - 133 


Total Impact Factor =43.362 

H-Index (SCOPUS)=6


Abstracts and Poster in National and International Congresses

1. G Perniola, A Casorelli, J Caccetta, F Lecce, V Di Donato, I Palaia, C Marchetti, F Tomao, A Musella, M Fischetti, F Vena, A Romito, M Di Feliciantonio, L Muzii, M Monti, P Benedetti Panici Preoperative ultrasound diagnosis of diaphragmatic spread in ovarian cancer patients: technique and accuracy. a pilot study INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 1 Nov 2017. 1434-1434.

2. Benedetti Panici P., Marchetti C., Musella A., Romito A., Vertechy L., Lecce F.,Tomao F., Di Donato V., Perniola G., Palaia I., Muzii L., Monti M.. “Trabectedin in Heavily Pretreated Recurrent Ovarian Cancer Patients: A Case-Control Study” Abstract at 16th Biennal Meeting of the International Gynecologic Cancer Society (IGCS)
Internationa Journal Of Gynecological Cancer 2016, Vol 26, Supp 3, 638. Lisbon, 29-31 October 2016

3. G. Perniola, A. Martoccia, A. Casorelli, A. Romito, J. Caccetta, M. Fischetti, F. Lecce, F. Tomao, V. Di Donato, L. Muzii, P. Benedetti Panici. “Accuracy of pelvic ultrasound in preoperative evaluation of uterine myomas: a prospective cohort study”. Abstracts at 26th World Congress on Ultrasound in Obstetrics and Gynecology of International Socety of Ultrasounds in Obstetrics and Gynecology (ISUOG) Utrasound in Obstetrics & Gynecology 2016; 48 (Suppl. 1):242. Rome, 25-28 September 2016

4. D. Lorusso, G. Fucà, I. Sabatucci, F. Lecce, S. Lepori, G. Maltese, A. Ditto, G. Bogani, V. Chiappa, F. Martinell1, C. Marchetti, I. Palaia, M.L. Carcangiu, P. Benedetti Panici, F. Raspagliesi “DOSE DENSE NEOADJUVANT CHEMOTHERAPY (NACT) WITH CARBOPLATIN-PACLITAXEL IN LOCALLY ADVANCED CERVICAL CANCER” Abstrat accepted as poster at XIX International Meeting of European Society of Gynecological Oncology (ESGO) The Internationa Journal of Gynecological Cancer 2015,Vol 25, Supp 9, 859-860. Nice 24-27 October 2015

5. Achilli C, Bergamini V, Candiani M, Garavaglia E, Lecce F, Maneschi F, Marana R, Muzii L, Seracchioli R, Spagnolo E, Vignali M, Zupi E, Benedetti Panici P. “Confronto tra tecnica di “stripping” e tecnica “combinata” escissione/coagulazione per il trattamento della cisti endometriosica finalizzato al risparmio del tessuto ovarico sano e della riserva ovarica: uno studio clinico randomizzato.” Abstrat selected as oral communication at IX nazional congress of “Società Italiana di Endoscopia Ginecologica” (SEGI). Milano 22-24 Maggio 2014

6. Chiara Achilli, Francesca Lecce, Violante Di Donato, Claudia Marchetti, Angela Musella, Innocenza Palaia, Giorgia Perniola, Ludovico Muzii, Pierluigi Benedetti Panici “CHIRURGIA PRIMARIA vs CHIRURGIA SECONDARIA NEL TRATTAMENTO DELL ‘ENDOMETRIOMA RICORRENTE: MAGGIOR DANNO DEL TESSUTO OVARICO SANO” Abstrat accepted as poster at Agui Congress (Associazione Ginecologi Universitari Italiani)/III National Congress AGIF (Associazione Italiana Ginecologi in Formazione) Roma 7 - 8 novembre 2013

7. Lecce F., Di Donato V., Muzii L., Benedetti Panici P. “ Uterine Leiomyomas: Therapeutic Management and Open Questions” Abstract selected as oral communication at XXV National Congress of SPIGC (Società Polispecialistica Italiana dei giovani Chirurghi) Bari, 13 - 15 June 2013

8. Domenici L, Di Donato V, Gasparri ML, Lecce F, Caccetta J, Panici PB. “SUCCESSFULL LAPAROTOMIC MIOMECTOMY OF A LARGE SUBSEROSAL MYOMA CAUSING HYDRONEPHROSIS AT 16TH WEEK OF PREGNANCY - A CASE REPORT”. Abstract selected as oral communication at XXV National Congress of SPIGC (Società Polispecialistica Italiana Giovani Chirurghi), Bari, 13-15 June 2013

9. Muzii L, Achilli C., Bergamini V., Candiani M., Garavaglia E., Lazzeri L., Lecce F., Maneschi F., Marana R., Serracchioli R., Spagnolo E., Vignali M., Benedetti Panici P. “Comparison between the stripping technique and the combined excisional/ablative technique for the treatment of bilateral ovarian endometriomas: a multicentric, randfoimized study” Abstract accepted as open communication at 43th AAGL Global Congress on Minimally Invasive Gynecology (American Association of Gynecologic Laparioscopists) Journal of Minimally Invasive Gynecology 21 (2014) S1-S44 (S16). Vancouver 17-21 November 2014

10.Muzii L., Bianchi A., Achilli C., Lecce F., Di Donato V., Marchetti C., Palaia I., Perniuola G., Benedetti Panici P. “Second surgery For Recurrent Endometriomas Is More Harmful to Healthy Ovarian Tissue Than First Surgery” Abstracts accepted as Open Commiunication at 42nd AAGL Global Congress of Minimally Invasive Gynecology (American Association of Gynecologic Laparioscopists) Journal of Minimally Invasive Gynecology 20 (2013) S1-S49 (S7). Washington D.C. 10-14 November 2013

11. D. Alvaro, R. Semeraro, C. Napoli, R. Gentile, V. Cardinale, M. Gatto, R. Venere, F. Lecce, U. Di Tondo, R. Brunelli, M.M. Anceschi, G. Carpino, E. Gaudio. “Isolation, culturing and differentiation of multipotent stem cells from human foetal biliary tree” Abstracts at The Liver Meeting 2010: American Association for the Study of Liver Diseases (AADLD) 61st Annual Meeting/Hepatology, volume 52, number 4(supp),405A . Boston Oct 29- Nov 02 2010

12. R. semeraro, C. Napoli, A. Torrice, R. Gentikle, V. Cardinale, M. Gatto, R. Venere, F. Lecce, U. Di Tondo, R. Brunelli, M.M. Anceschi, G. Carpino, E. Gaudio, D. Alvaro. “Isolation, culturing and differentiation of multipotent stem cells from human foetal biliary tree” Abstrtact at the 43th Monothematic Conference 2010 of the A.I.S.F. (Italian Association for the Study of the Liver) Rome, 24-27 February 2010


Oral Comunication

Oral communication at XXV National Congress of SPIGC (Società Polispecialistica Italiana dei giovani Chirurghi) entitled “ Uterine Leiomyomas: Therapeutic Management and Open Questions” (Bari, 13 - 15 June 2013)

Oral comunication at annual meeting of AGUI(Associazione Ginecologi Universitari Italiani) entitled: “Contraccezione e la prevenzione delle malattie sessualmente trasmesse” (Bologna 13-14 Novembre 2015)

Oral Comunication at “Corso SIEOG, Società Italiana diEcografia di Ostetrica e Ginecologica e Metodologie Biofisiche: Corso di ecografia di base” entitled: “Modificazioni endometriali nelle diverse fasi del ciclo fertile, modificazioninelle diverse età della donna” Roma 17 Marzo 2018


Honours and awards

Winner of University Research Project “Progetto di Avvio alla Ricerca 2014” entitled “VULVODYNIA: IS DUE TO AN ENHANCED SYNTHESIS OF PROINFLAMMATORY MOLECULES? LOOKING FOR THE ACHILLE'S HEEL" in collaboration with Dott.ssa Lavinia Domenici
Protocol number: C26N14ASJW

Protocol numbers: C26N152JTF


Clinical Trial

Sub-Investigator of phase-III clinical trial entitled “MILO Study (MEK Inhibitor in Low-grade Serous Ovarian Cancer): A Multinational, Randomized, Open-Label Phase 3 Study of MEK162 Vs Physician’s Choise Chemotherapy in Patients with Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Falloppian tube or Primary Peritoneum” 
Protocol numbers: ARRAY-162-311

Sub-investigator of phase-II clinical trial entitled: “A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Efficacy and Safety of Farletuzumab (MORAB 003) in Combination With Carboplatin Plus Paclitaxel of Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Subjects With Low CA125 Platinum-Sensitive Ovarian Cancer”
Protocol numbers: MORAB-003-001

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